HypertensionCohort study
Reduction in blood pressure for people with isolated diastolic hypertension and cardiovascular outcomes
- Retrospective cohort study
Authors' conclusion
Our analysis of a large-scale epidemiological dataset demonstrated a relationship of reduction in DBP with a reduced risk for CVD events in individuals with IDH.
Study context
- Population
- Adults with isolated diastolic hypertension (SBP <140 mmHg, diastolic BP (DBP) ≥90 mmHg), no blood pressure (BP)-lowering medication or prior cardiovascular disease (CVD) at baseline
- Participants
- 71,297 adults
- Exposure
- DBP <90 mmHg vs ≥90 mmHg at 1 year
- Outcome
- Composite of:
- MI
- Stroke
- All-cause death
- Follow-up
- Mean 1100 ± 859 days
Main finding
Composite CVD events
Hazard ratio
0.75
95% CI 0.67–0.83
DBP <90 mmHg vs DBP ≥90 mmHg
HR 0.75 (95% CI 0.67–0.83)
As reported in the abstract
- Composite CVD endpoints recorded
- 1317
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Composite CVD events per 5 mmHg DBP reduction over 1 year | 0.92 (0.89–0.95) | |
| 0.512Hazard ratio (log scale) |
Sensitivity analyses
- Results consistent across multiple sensitivity analyses
Original publication
Reduction in blood pressure for people with isolated diastolic hypertension and cardiovascular outcomes. Eur J Prev Cardiol. Published 23 November 2022. doi:10.1093/eurjpc/zwac278
Summarised from the published abstract; every number is checked against it