Prevention & lipidsCohort study
Refined physical activity recommendations considering cardiovascular disease risk stratification: a cohort study
- Prospective cohort study
- UK Biobank
- accelerometer-derived physical activity (PA)
- compositional data analysis
Authors' conclusion
The optimal VPA threshold should be underscored, especially for high- or very high-risk populations.
Study context
- Population
- UK Biobank participants with accelerometer-derived PA and sedentary time
- Participants
- 72,884 participants
- Exposure
- Accelerometer-derived PA across SCORE2 risk strata
- Outcome
- Incident CVD
Main finding
As reported in the abstract
Incident CVD per 150-min/week increase in MVPA, by risk stratum
| Group | Lower hazard |
|---|---|
| Very high risk | 20% (95% CI 14-26%) |
| High risk | 16% (14-18%) |
| Low-to-moderate risk | 16% (13-19%) |
Observational data: associations, not effects.
Further findings
Reallocating sedentary time to moderate-to-vigorous PA (MVPA) (compositional analysis)
- Low-to-moderate risk: replacing 300 min/week of sedentary time with any MVPA combination provided benefits
- High risk: benefits may diminish beyond VPA of 60 min/week
- Very high risk: benefits may diminish beyond VPA of 42 min/week
Original publication
Refined physical activity recommendations considering cardiovascular disease risk stratification: a cohort study. Eur J Prev Cardiol. Published 28 January 2026. doi:10.1093/eurjpc/zwag054
Summarised from the published abstract; every number is checked against it