Association Between Life's Essential 8 and Cardiovascular, Cancer, and Other Cause Mortality: The REGARDS Study
Authors' conclusion
Better LE8-quantified CVH was associated with lower CVD and cancer mortality in a competing risk framework. These findings underscore the significance of lifestyle modifications in mortality risk reduction, advocating for their incorporation into clinical guidelines and preventive counseling.
Study context
- Population
- Black and White adults from the 48 contiguous U.S. states, recruited 2003 to 2007 (REGARDS study), without prevalent cardiovascular disease (CVD) or cancerincluded participants, of 30,239 recruited, mean age 65 ± 9 years, 52% female, 44% Black adults
- Participants
- 11,385 participants
- Exposure
- Higher cardiovascular health (CVH) compared to low CVH levels
- Outcome
- Distribution of LE8-quantified CVH
Methodological detailscompeting risk framework, adjusted cause-specific hazard models
- Competing risk framework
- Adjusted cause-specific hazard models
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD, cancer, and non-CVD, noncancer mortalityHigh CVHvs low CVHCVD mortality · competing risks; adjusted cause-specific hazard models | 0.37 (0.28–0.49) | |
| CVD, cancer, and non-CVD, noncancer mortalityHigh CVHvs low CVHCancer mortality · competing risks; adjusted cause-specific hazard models | 0.48 (0.36–0.66) | |
| CVD, cancer, and non-CVD, noncancer mortalityHigh CVHvs low CVHnon-CVD, noncancer mortality · competing risks; adjusted cause-specific hazard models | 0.39 (0.32–0.48) | |
| 0.20.5125Hazard ratio (log scale) |
Deaths by cause · median (IQR) follow-up of 14 (IQR: 8-17) years
- Died from CVD
- 8%
- Died from cancer
- 7%
- Died from other causes
- 17%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Life's Essential 8 and Cardiovascular, Cancer, and Other Cause Mortality: The REGARDS Study. JACC Adv. Published 8 May 2025. doi:10.
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