Prevention & lipidsMeta-analysis
Regional and temporal differences in the associations between cardiovascular disease and its classic risk factors: an analysis of 49 cohorts from 11 European countries
- Pooled analysis of cohort studies
- multicentre
- 49 cohorts
- 11 European countries
- meta-regression
Authors' conclusion
The results demonstrate that all classic CVD risk factors are still relevant in Europe, irrespective of regional area.
Study context
- Population
- Individuals from 49 cohorts in 11 European countries (baseline 1982–2012)
- Participants
- 553,818 individuals · 49 cohorts
- Comparison
- Cardiovascular disease (CVD) risk factor associations across European regions and over time
- Outcome
- CVD events:
- CHD
- Stroke
- Follow-up
- Maximum of 10 years
Pooled result
As reported in the abstract
Risk factor-CVD associations by region and by decade
- Men: slightly higher HR in southern Europe vs other regions
- P = 0.043 for overall difference
- Diabetes: slightly lower HR in central Europe vs other regions
- P = 0.022 for overall difference
- HR decrease per decade, non-HDL cholesterol (per mmol/L)
- 7% (95% CI, 3-10%)
- HR decrease per decade, SBP (per 20 mmHg)
- 4% (95% CI, 1-8%)
- HR increase per decade, body mass index (BMI) (per 10 kg/m²)
- 7% (95% CI, 1-13%)
Original publication
Regional and temporal differences in the associations between cardiovascular disease and its classic risk factors: an analysis of 49 cohorts from 11 European countries. Eur J Prev Cardiol. Published 17 November 2023. doi:10.1093/eurjpc/zwad359
Summarised from the published abstract; every number is checked against it