Prevention & lipidsCohort study
Relation of Life’s Essential 8 to the genetic predisposition for cardiovascular outcomes and all-cause mortality: results from a national prospective cohort
- Prospective cohort study
- national cohort
- UK Biobank
Authors' conclusion
Ideal CVH was associated with lower risks of cardiovascular outcomes and all-cause mortality, with a more pronounced association observed in individuals with high PRS for CVD.
Study context
- Population
- UK Biobank participants; LE8 from nicotine exposure, physical activity, diet, sleep, BMI, BP, blood glucose and blood lipids; genetic predisposition by polygenic risk score (PRS)
- Participants
- 254,783 participants
- Exposure
- Moderate or high vs low cardiovascular health (LE8), across genetic predisposition (PRS)
- Outcome
- CV outcomes (CV mortality, incident CVD) and all-cause mortality
- Follow-up
- Median 12.53 years
Main finding
As reported in the abstract
Adverse health outcomes:
- CV outcomes
- All-cause mortality
Hazard ratio
0.33 to 0.81
- Events: all-cause mortality
- 10 257 of 197 473
- Events: CV mortality
- 2074 of 215 675
- Events: incident cardiovascular disease (CVD)
- 71 774 of 215 675
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD mortality, high PRS (subgroup) · high PRS | 0.26 (0.18–0.39) | |
| 0.20.5125Hazard ratio (log scale) |
Proportion of outcomes attributable to moderate or high LE8
- Attributable proportion
- 16.1∼69.8%
Mediation of PRS–outcome associations by LE8
- Proportion mediated by LE8 (up to)
- 51.2%
Original publication
Relation of Life’s Essential 8 to the genetic predisposition for cardiovascular outcomes and all-cause mortality: results from a national prospective cohort. Eur J Prev Cardiol. Published 25 May 2023. doi:10.1093/eurjpc/zwad179
Summarised from the published abstract; every number is checked against it