Coronary disease & ACSSecondary analysis
Relationship between achieved LDL-C and saphenous vein graft patency: a post hoc analysis of the NEWTON-CABG CardioLink-5 study
- Post hoc analysis of the NEWTON-CABG CardioLink-5 randomised trial
Authors' conclusion
LDL-C achieved over the range in this study was associated with SVG-related angiographic outcomes, suggesting LDL-C may have some role in SVG patency.
Study context
- Population
- Adults on moderate- to high-intensity statins undergoing CABG with ≥2 saphenous vein graft (SVGs)
- Participants
- 499 adults · 1,198 SVGs
- Comparison
- Achieved month 3 LDL-C and SVG patency
- Primary endpoint
- Proportion of SVGs with ≥50% occlusion on coronary CT angiography or clinically indicated invasive angiography
- Follow-up
- 24 months
Primary result
As reported in the abstract
SVG ≥50% occlusion by achieved LDL-C
- Month 3 LDL-C · per 1 mmol/L decrement; Pinteraction = 0.79
- OR 0.74; P = 0.005
- LDL-C change baseline to month 3 · per 1 mmol/L decrease; Pinteraction = 0.84
- OR 0.78; P = 0.03
Secondary outcomes
Mean LDL-C
mmol/L
- Baseline
- 2.04
- Month 3
- 1.03
Original publication
Relationship between achieved LDL-C and saphenous vein graft patency: a post hoc analysis of the NEWTON-CABG CardioLink-5 study. Eur J Prev Cardiol. Published 30 March 2026. doi:10.1093/eurjpc/zwag190
Summarised from the published abstract; every number is checked against it