Heart failure & cardiomyopathiesMeta-analysis
Relationship Between Ambulatory Pulmonary Artery Pressures and Heart Failure Hospitalizations in Patients With Chronic Heart Failure
- Retrospective pooled analysis of 4 CardioMEMS studies
- landmark analysis
Authors' conclusion
Baseline PAP and change in PAP from baseline to 6 months (systolic, diastolic, and mean) were independent predictors of HFH within 2 years.
Study context
- Population
- Patients with chronic heart failure (HF) with an ambulatory pulmonary artery pressure (PAP) monitor (CardioMEMS), from CHAMPION, GUIDE-HF, US PAS and MEMS-HF, regardless of treatment assignment
- Participants
- 4,342 patients · 4 studies
- Outcome
- HF hospitalization (HFH) predicted by baseline systolic, diastolic and mean PAPs and their change from baseline to 6 months
- Follow-up
- 2 years
Pooled result
As reported in the abstract
Baseline diastolic PAP, independent predictor of heart failure hospitalization (HFH): HR (95% CI 1.035-1.050), P < 0.0001
1.043
Change in diastolic PAP baseline to 6 months (continuous), independent predictor of HFH (landmark analysis): HR (95% CI 1.035-1.0506), P < 0.0001
1.047
Diastolic PAP decrease >2 mm Hg vs no change (baseline to 6 months): decrease in HFH, P < 0.0001
16.1%
Diastolic PAP increase >2 mm Hg vs no change (baseline to 6 months): increase in HFH, P < 0.0001
50.1%
Further pooled results
Systolic and mean PAPs; HFrEF (n = 2,562) and HFpEF (n = 1,454) subgroups
- Results comparable for systolic and mean PAPs and for HFrEF and HFpEF
Original publication
Summarised from the published abstract; every number is checked against it