Heart failure & cardiomyopathies
Relationship Between Cardiac Structure and Function With Renal Function Trajectory and Outcomes in Patients With Heart Failure: Insights From the PARAGON-HF Trial
Authors' conclusion
In the PARAGON-HF echocardiographic substudy, higher LV mass and filling pressures were independently associated with more profound kidney function decline, and higher LV mass and volume, as well as impaired right ventricular structure and function, were each associated with renal events.
Study context
- Population
- Patients with HFpEF in the PARAGON-HF echocardiographic substudy
- Participants
- 1,097 patients
- Comparison
- Echocardiographic measures of cardiac structure and function (per 1 SD) vs renal function trajectory and renal outcomes
- Primary endpoint
- Annual change in eGFR and composite renal outcome (≥50% eGFR decline from baseline, end-stage renal disease or renal death)
- Follow-up
- Median 2.9 years
Methodological detailsechocardiographic substudy
- Echocardiographic substudy
Primary result
As reported in the abstract
Composite renal events
28
0.9 per 100 person-years
Higher left ventricular (LV) mass index: annual eGFR decline per 1 higher SD
−0.4 mL/min/1.73 m²/y
95% CI −0.7 to −0.1
Higher E/average e' ratio: annual eGFR decline per 1 higher SD
−0.4 mL/min/1.73 m²/y
95% CI −0.7 to −0.1
Original publication
Relationship Between Cardiac Structure and Function With Renal Function Trajectory and Outcomes in Patients With Heart Failure: Insights From the PARAGON-HF Trial. Circ Heart Fail. Published 30 August 2024. doi:10.
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