HypertensionCohort study
Relationship Between Renin, Aldosterone, Aldosterone-to-Renin Ratio and Arterial Stiffness and Left Ventricular Mass Index in Young Adults
- Prospective cohort study
- population-based
- longitudinal
Authors' conclusion
Aldosterone concentration and aldosterone-to-renin ratio were positively associated with the LVMI in young males and females, respectively, independently of systolic blood pressure.
Study context
- Population
- Young adults (offspring of the Raine Study, Western Australia) at 17 and 27 years of age859 at 17 y
- Exposure
- Renin, aldosterone and aldosterone-to-renin ratio vs arterial stiffness and LV mass index
- Outcome
- Arterial stiffness (pulse wave velocity, aortic augmentation index, aortic distensibility) and LV mass index
Main finding
As reported in the abstract
LV mass index, by primary aldosteronism biomarkers · 27 years of age
- Aldosterone (males)
- β 0.009 (95% CI 0.001–0.017); P = 0.027
- Aldosterone-to-renin ratio (females)
- β 0.098 (95% CI 0.001–0.196); P = 0.050
Observational data: associations, not effects.
Further findings
Renin concentration, females vs males
- At 17 y: 20.7 mU/L vs 25.7 mU/L
- P < 0.001
- At 27 y: 12.0 mU/L vs 15.4 mU/L
- P < 0.001
Aldosterone-to-renin ratio, females vs males
- At 17 y: 18.2 vs 13.5
- P < 0.001
- At 27 y: 21.0 vs 15.6
- P < 0.001
Original publication
Relationship Between Renin, Aldosterone, Aldosterone-to-Renin Ratio and Arterial Stiffness and Left Ventricular Mass Index in Young Adults. Circulation. Published 1 October 2024. doi:10.1161/circulationaha.124.070039
Summarised from the published abstract; every number is checked against it