Valvular & structural heart disease
Relationship between the left-to-right ventricular volume ratio and aortic regurgitation severity: an echocardiographic and cardiac magnetic resonance imaging study
Authors' conclusion
The LV/RV ratio is a reliable and individualized marker of LV remodeling in chronic AR. These findings support its potential role in clinical assessment and further evaluation in outcome studies.
Study context
- Population
- Patients with chronic aortic regurgitation who underwent echocardiography and CMRpatients with chronic aortic regurgitation (AR) (median age: 55 years, 18% women)
- Participants
- 258 patients
- Comparison
- Left ventricular (LV)/RV ratio against significant AR, defined as Grades 3-4 on echocardiography (Echo) or aortic regurgitant fraction (AR-RegFrac) ≥ 33% on CMR
- Outcome
- LV/RV ratio
Main finding
As reported in the abstract
- Median LV/RV ratio
- 1.5 [1.3-1.9]
- Increased with AR severity
- P < 0.001
Further findings
Correlation of LV/RV ratio with AR-RegFrac
- R
- 0.67
- P
- P < 0.001
- Correlated more strongly with AR-RegFrac than conventional LV measures
Identification of significant AR by LV/RV ratio
- Echo, AUC
- 0.77
- CMR, AUC
- 0.83
- Threshold of 1.5: Se
- 71-84%
- Threshold of 1.5: Sp
- 77-75%
- Threshold of 1.8: Sp (for both modalities)
- 91%
- 1.5 provided balanced sensitivity and specificity
- 1.8 ruled in significant AR with high specificity
LV/RV ratio by age, sex and subgroups
- Did not vary significantly by age or sex and showed consistent performance across subgroups
Original publication
Relationship between the left-to-right ventricular volume ratio and aortic regurgitation severity: an echocardiographic and cardiac magnetic resonance imaging study. Eur Heart J Cardiovasc Imaging. Published 26 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →