Coronary disease & ACSCohort study
Relative Fractional Flow Reserve Increase and Final Fractional Flow Reserve After Percutaneous Coronary Intervention
- Registry-based cohort study
- international registry
Authors' conclusion
Relative FFR increase after PCI provides prognostic implications comparable with post-PCI FFR.
Study context
- Population
- Patients with pre-PCI fractional flow reserve (FFR) ≤0.80 undergoing PCI (International Post PCI FFR Extended Registry)
- Participants
- 1,497 patients
- Exposure
- ΔFFR% <15.0% vs ≥15.0%; post-PCI FFR ≤0.80 vs >0.80
- ΔFFR% ≥15.0%n = 1,148reference
- ΔFFR% <15.0%n = 349
- Post-PCI FFR >0.80n = 1,279reference
- Post-PCI FFR ≤0.80n = 218
- Outcome
- TVF (cardiac death, target vessel MI or target vessel revascularization (TVR))
- Follow-up
- 5 years
Main finding
As reported in the abstract
5-year TVF by ΔFFR% and post-PCI FFR cutoffs
- Post-PCI FFR ≤0.80 had increased target vessel failure (TVF) vs >0.80, regardless of sufficient (≥15.0%) or insufficient (<15.0%) relative FFR increase
- cutoffs 15.0% (ΔFFR%) and 0.80 (post-PCI FFR) by maximally selected log-rank statistics
Observational data: associations, not effects.
Further findings
| Outcome | ΔFFR% ≥15.0% | ΔFFR% <15.0% | Post-PCI FFR >0.80 | Post-PCI FFR ≤0.80 | P value |
|---|---|---|---|---|---|
| Non-TLR TVR, ΔFFR% ≥15.0% (subgroup) | Not reported in the abstract | Not reported in the abstract | 2.2% | 6.0% | P = 0.015 |
| TLR, ΔFFR% <15.0% (subgroup) | Not reported in the abstract | Not reported in the abstract | 6.6% | 17.0% | P = 0.008 |
TVF, post-PCI FFR ≤0.80 vs >0.80 by ΔFFR% (subgroup)
- Increased TVF with post-PCI FFR ≤0.80 regardless of sufficient or insufficient relative FFR increase
Original publication
Relative Fractional Flow Reserve Increase and Final Fractional Flow Reserve After Percutaneous Coronary Intervention. JACC Cardiovasc Interv. Published 27 April 2026. doi:10.1016/j.jcin.2026.02.020
Summarised from the published abstract; every number is checked against it