Pulmonary vascular disease & thromboembolism

Relaxin Mimetic in Pulmonary Hypertension Associated with Left Heart Disease: Design and Rationale of Re-PHIRE

ESC Heart FailPublished phase 2b, randomized, double-blind, placebo-controlled, multicentre, dose-ranging study

Study context

Population
Patients with pulmonary hypertension associated with left heart disease (PH-LHD) in the context of heart failure (HF)planned, to be randomized to four treatment groups
Participants
220 patients
Planned comparison
AZD3427 versus placebo
Primary endpoint
Change in pulmonary vascular resistance
Follow-up
After 24 weeks of treatment

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Relaxin Mimetic in Pulmonary Hypertension Associated with Left Heart Disease: Design and Rationale of Re-PHIRE. ESC Heart Fail. Published 20 January 2025. doi:10.1002/ehf2.15203

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