HypertensionSecondary analysis
Remnant cholesterol and intensive blood pressure control in older patients with hypertension: a post hoc analysis of the STEP randomized trial
- Post hoc analysis of the STEP randomised trial
- subgroup analysis by baseline remnant cholesterol (RC) tertile
Authors' conclusion
Baseline RC concentrations were associated with the effects of intensive SBP lowering on the primary composite cardiovascular outcome and all-cause mortality in hypertensive patients.
Study context
- Population
- Older patients with hypertension (STEP trial)
- Participants
- 8,206 patients
- Comparison
- Intensive vs Standard
- Primary endpoint
- Composite of:
- Stroke
- ACS
- Acute decompensated HF
- Coronary revascularization
- AF
- CV death
- Follow-up
- Median 3.33 years
Primary result
Primary composite outcome by baseline RC tertile
Adjusted hazard ratio
0.67
95% CI 0.46–0.96
Highest RC tertile vs Standard
adjusted HR 0.67 (95% CI 0.46–0.96)
As reported in the abstract
- Heterogeneity, upper two tertiles vs lowest tertile
- P for interaction = 0.033
Further findings
| Outcome | adjusted HR (95% CI) | |
|---|---|---|
| All-cause mortality by baseline RC tertile | 0.42 (0.22–0.80) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- All-cause mortality by baseline RC tertile: P for interaction <0.0001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Remnant cholesterol and intensive blood pressure control in older patients with hypertension: a post hoc analysis of the STEP randomized trial. Eur J Prev Cardiol. Published 3 January 2024. doi:10.1093/eurjpc/zwae001
Summarised from the published abstract; every number is checked against it