Prevention & lipidsCohort study
Remnant cholesterol, low-density lipoprotein cholesterol, and incident cardiovascular disease among Koreans: a national population-based study
- Retrospective cohort study
- national population-based
Authors' conclusion
Combined high remnant-C and LDL-C levels confer a higher CVD risk than that individually. Elevated remnant-C values independent of LDL-C levels were associated with a risk of incident CVD.
Study context
- Population
- Koreans aged 40–70 years without cardiovascular disease (CVD) history, with ≥2 health screenings 2009–2011, national health insurance data45.6% women
- Participants
- 3,686,034 participants
- Exposure
- Combinations of high vs low low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol
- Outcome
- CVD
- Follow-up
- Between 2014 and 2017
Main finding
As reported in the abstract
Each group vs referenceHazard ratio (95% CI)
High LDL-C and high remnant-C
1.266(1.243–1.289)
High LDL-C only
1.098(1.083–1.113)
High remnant-C only
1.102(1.087–1.118)
- Cardiovascular events
- 144 004
Observational data: associations, not effects.
Further findings
CVD risk by remnant cholesterol (remnant-C) level, adjusted incl. LDL-C
- Continuous and linear increase in CVD risk with higher remnant-C
Remnant-C ≥ 0.8 mmol/L and CVD, across strata (subgroups)
- Association with increased CVD risk consistent across various strata
Original publication
Remnant cholesterol, low-density lipoprotein cholesterol, and incident cardiovascular disease among Koreans: a national population-based study. Eur J Prev Cardiol. Published 8 February 2023. doi:10.1093/eurjpc/zwad036
Summarised from the published abstract; every number is checked against it