Prevention & lipidsCohort study
Remnant cholesterol reduction for atherosclerotic cardiovascular disease prevention: modelling in the Copenhagen General Population Study
- Prospective cohort study with modelling
- modelling of cohort data
Authors' conclusion
In women and men, aggressive lowering of remnant cholesterol has the potential for substantial ASCVD reduction.
Study context
- Population
- Women and men without a history of atherosclerotic cardiovascular disease (ASCVD), Copenhagen General Population Study, recruited 2003–2015
- Participants
- 56,422 vs 43,952
- Exposure
- Lower vs higher remnant cholesterol levels
- Womenn = 56,422
- Menn = 43,952
- Outcome
- Incident ASCVD (modelled absolute 10-year risk reduction)
- Follow-up
- Median 12 years
Main finding
As reported in the abstract
Absolute 10-year ASCVD risk reduction, very-high CV risk, 2 mmol/L (77 mg/dL) lower remnant cholesterol from 3 mmol/L (116 mg/dL)
Statin users
Statin non-users
Observational data: associations, not effects.
Further findings
Absolute 10-year ASCVD risk reduction, very-high CV risk, 1 mmol/L (39 mg/dL) lower remnant cholesterol
Statin users
Statin non-users
events
| Outcome | Women | Men |
|---|---|---|
| Incident ASCVD during follow-up · median follow-up 12 years | 4946 | 6043 |
Original publication
Remnant cholesterol reduction for atherosclerotic cardiovascular disease prevention: modelling in the Copenhagen General Population Study. Eur J Prev Cardiol. Published 8 April 2025. doi:10.1093/eurjpc/zwaf203
Summarised from the published abstract; every number is checked against it