Coronary disease & ACSRandomised controlled trial
Remote ischaemic pre-conditioning, kidney injury, and outcomes after coronary angiography and intervention: a randomized trial
- Randomised controlled trial
- multicentre
- sham-controlled
Authors' conclusion
Among at-risk patients undergoing CAG or PCI, the incidence of CA-AKI was lower in patients receiving delayed compared with sham RIPC.
Study context
- Population
- Patients at risk of contrast-associated acute kidney injury (CA-AKI) undergoing elective coronary angiography (CAG) or percutaneous coronary intervention (PCI)467 (93.2%) completed day-90 assessments
- Participants
- 501 patients
- Comparison
- Delayed remote ischaemic pre-conditioning (RIPC) vs sham RIPC
- Delayed RIPCn = 250
- Sham RIPCn = 251reference
- Primary endpoint
- Incidence of AKI (KDIGO criteria)
Primary result
CA-AKI
Odds ratio
0.4
95% CI 0.17–0.94
P = 0.03
By group
Delayed RIPC vs Sham RIPC
OR 0.4 (95% CI 0.17–0.94); P = 0.03
As reported in the abstract
Original publication
Remote ischaemic pre-conditioning, kidney injury, and outcomes after coronary angiography and intervention: a randomized trial. Eur Heart J. Published 11 March 2025. doi:10.1093/eurheartj/ehaf135
Summarised from the published abstract; every number is checked against it