Randomised controlled trial
Remote Ischemic Conditioning in Pediatric Cancer Patients Receiving Anthracycline Chemotherapy
- Randomised controlled trial
- phase 2
- sham-controlled
- single-blind
Authors' conclusion
RIC did not exhibit cardioprotective effects in childhood cancer patients receiving anthracycline-based chemotherapy.
Study context
- Population
- Pediatric cancer patients receiving anthracycline-based chemotherapy
- Participants
- 68 patients
- Comparison
- Remote ischemic conditioning (RIC) vs sham intervention
- RICn = 34
- Shamn = 34reference
- Primary endpoint
- Plasma high-sensitivity cardiac troponin T (hs-cTnT) level
Primary result
As reported in the abstract
Plasma hs-cTnT
Progressive increase across time points in RIC
P < 0.001
Progressive increase across time points in sham
P < 0.001
No significant differences between groups at each time point
all P > 0.05
Secondary outcomes
LV tissue Doppler and strain parameters
- No significant differences between groups at each time point
- all P > 0.05
Safety
HF or cardiac arrhythmias
- No patients developed HF or cardiac arrhythmias
Original publication
Remote Ischemic Conditioning in Pediatric Cancer Patients Receiving Anthracycline Chemotherapy. JACC CardioOncol. Published 21 March 2023. doi:10.1016/j.jaccao.2022.11.020
Summarised from the published abstract; every number is checked against it