Heart failure & cardiomyopathies
Renal Dysfunction is a Time-Varying Risk Predictor of Sudden Cardiac Death in Heart Failure
Authors' conclusion
The addition of eGFR to current eligibility criteria may be useful for risk assessment of SCD, although its predictive power wanes over time. Roughly a quarter of the SCD occurred within 3 months after discharge in patients with CHF.
Study context
- Population
- Patients with New York Heart Association (NYHA) class II or III congestive heart failure (CHF), 2008–2015
- Participants
- 1,676 patients
- Exposure
- Risk predictors of sudden cardiac death (SCD)
- Outcome
- SCD
- Follow-up
- Median 25 (4-70) months
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
eGFR < 30 ml/min/1.73 m²
1.73(1.11–2.70)
P = 0.01LVEF ≤ 35%
2.31(1.47–3.66)
P < 0.01- Patients with SCD
- 198 (11.8%)
- SCD within 3 months of discharge
- 23%
Observational data: associations, not effects.
Further findings
Addition of estimated glomerular filtration rate (eGFR) to left ventricular ejection fraction (LVEF) for SCD prediction
- Improved C-index
- P = 0.04
- Net reclassification improvement
- P = 0.01
- Integrated discrimination improvement
- P = 0.03
- Predictive power of eGFR declined time-dependently over 2 years
Original publication
Renal Dysfunction is a Time-Varying Risk Predictor of Sudden Cardiac Death in Heart Failure. ESC Heart Fail. Published 10 June 2024. doi:10.
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