Heart failure & cardiomyopathies
Renin, Aldosterone, and Treatment Response to Dapagliflozin, Spironolactone, and Their Combination: An Analysis From SOGALDI-PEF
Authors' conclusion
Low plasma renin levels (≤21 mU/L) identify a high BP, sodium overload state and predict a more pronounced BP reduction with the spironolactone/dapagliflozin combination compared with dapagliflozin alone.
Study context
- Population
- Patients with HFpEFcrossover
- Participants
- 106 patients
- Comparison
- Spironolactone/dapagliflozin combination vs dapagliflozin alone, by baseline renin tertile
Methodological detailscrossover
- Crossover
Primary result
As reported in the abstract
SBP change by baseline renin tertile
Spironolactone/dapagliflozin vs DapagliflozinDifference, mm Hg (95% CI)
Tertile 1 (renin ≤21 mU/L)
−10.9(−16.4 to −5.4)
Tertile 2
−5.6(−11.3 to 0.02)
Tertile 3
1.5(−4.1 to 7.0)
Further findings
Baseline renin
- Median (percentile 25-75) renin, mU/L
- 29.7 (17.6-61.6)
- Low renin (tertile 1) vs tertile 2/3: higher SBP/DBP, serum sodium, lateral E/e', pulse wave velocity and peripheral edema
Echocardiographic parameters and pulse wave velocity
- Followed a similar pattern
Correlation of plasma renin and aldosterone
- Poor correlation (rho)
- 0.15; P = 0.12
Original publication
Renin, Aldosterone, and Treatment Response to Dapagliflozin, Spironolactone, and Their Combination: An Analysis From SOGALDI-PEF. JACC Heart Fail. Published 26 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →