Pulmonary vascular disease & thromboembolismTrial design
Reperfusion strategies for acute pulmonary embolism: Design and rationale of RECONNECT-PE—A living systematic review and meta-analysis
- living systematic review and meta-analysis
- frequentist network meta-analysis framework
- stratified by pulmonary embolism (PE) severity (high- and intermediate-risk)
- new eligible trials added prospectively
Study context
- Population
- Adult patients with high- or intermediate-risk acute pulmonary embolism (PE)23 randomized controlled trials (RCTs) included as of the initial search on 28 May 2025, thirteen additional ongoing trials identified for future inclusion
- Planned comparison
- reperfusion strategies vs standard of care
No results yet. This paper sets out the design of a trial; its results are to come.
Further findings
Trials identified · initial search on 28 May 2025
- RCTs included
- 23
- Additional ongoing trials identified for future inclusion
- Thirteen
- Ongoing trials with clinical outcomes, intermediate-risk PE: PEITHO-3, HI-PEITHO, PEERLESS II, PE-TRACT, and PRAGUE-26
- Ongoing trials with clinical outcomes, high-risk PE: CATCH-PE II, PERSEVERE, and TORPEDONL
- design and rationale; review is ongoing
Original publication
Reperfusion strategies for acute pulmonary embolism: Design and rationale of RECONNECT-PE—A living systematic review and meta-analysis. Am Heart J. Published 3 February 2026. doi:10.1016/j.ahj.2026.107365
Summarised from the published abstract; every number is checked against it