Acute cardiac care & resuscitation
Repolarisation abnormalities and outcomes among patients with cardiac arrest
Authors' conclusion
TpTe interval prolongation, but not QTc interval prolongation, was associated with increased in-hospital mortality in patients resuscitated from cardiac arrest.
Study context
- Population
- Adults with OHCA or in-hospital cardiac arrest after return of spontaneous circulation (ROSC) with an electrocardiogram (ECG) within 24 h of ROSC
- Participants
- 284 vs 310
- Exposure
- T-peak to T-end (TpTe) and QTc prolongation vs no prolongation
- TpTe prolongationn = 284
- QTc prolongationn = 310
- Outcome
- In-hospital mortality and favourable neurologic outcome at hospital discharge
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
QTc prolongationin-hospital mortality
1.27(0.75–2.14)
P = 0.37QTc prolongationfavourable neurologic outcome
0.88(0.50–1.54)
P = 0.65TpTe prolongationin-hospital mortality
1.69(1.01–2.85)
P = 0.05TpTe prolongationfavourable neurologic outcome
0.78(0.45–1.37)
P = 0.39Observational data: associations, not effects.
Further findings
Initial shockable rhythm, by TpTe prolongation
- TpTe prolongation vs none
- 35.6% vs. 19.5%, P < 0.001
Initial lactate, by TpTe prolongation
- TpTe prolongation vs none (mmol/L)
- 8.6 vs. 7.4 mmol/L, P = 0.03
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Repolarisation abnormalities and outcomes among patients with cardiac arrest. Eur Heart J Acute Cardiovasc Care. Published 27 May 2025. doi:10.
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