Coronary disease & ACSCohort study
Residential exposome and the risk of coronary obstruction and myocardial ischaemia detected by coronary computed tomography
- Registry-based cohort study
- consecutive patients
- propensity-score adjusted
Authors' conclusion
We found no clear environmental associations with CT-derived coronary obstruction or ischaemia.
Study context
- Population
- Consecutive patients screened by coronary computed tomography angiography (CCTA) for stable chest pain, 2019–2020420 FFRCT analyses
- Participants
- 2,620 patients
- Exposure
- Residential air pollution, noise, and green exposure and CT-derived coronary obstruction and ischaemia
- Outcome
- Obstructive CAD (OCAD, stenosis ≥50%) and abnormal FFRCT (≤80%)
Main finding
As reported in the abstract
Associations of PM2.5, NO2, major road distance, airport distance, vegetation index with OCAD and abnormal FFRCT
Obstructive coronary artery disease (OCAD)
518 (20%)
Abnormal FFRCT
276 (11%)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Airport distance, OCAD vs no OCAD (univariable) · OCAD risk, per 1 km, univariable | 0.983 (0.974–0.992) | |
| Abnormal FFRCT, high-risk patients (Framingham >20%, subgroup) · per 1 km, after PS adjustment | 0.634 (0.421–0.926) | |
| 0.512Odds ratio (log scale) |
- Airport distance, OCAD vs no OCAD (univariable) — Distance to airport, OCAD vs no OCAD
- 10.841 (7.869-19.022) km vs. 12.297 (8.691-22.843) km, P < 0.001
Airport distance, OCAD vs no OCAD (univariable)
- People living closer to the airport had more cardiovascular (CV) and socio-economic risk factors
Original publication
Residential exposome and the risk of coronary obstruction and myocardial ischaemia detected by coronary computed tomography. Eur J Prev Cardiol. Published 19 February 2025. doi:10.1093/eurjpc/zwaf090
Summarised from the published abstract; every number is checked against it