Coronary disease & ACSCohort study
Residual Cardiovascular Biomarkers After Medical Therapy and Their Prognostic Implications Following Percutaneous Coronary Intervention
- Registry
Authors' conclusion
Among medically treated patients following PCI, elevated fibrinogen levels were associated with adverse outcomes. Further studies are warranted to clarify these associations and to determine whether adjunctive therapies can improve outcomes in this high-risk group. (Gyeongsang National University Hospital [GNUH] Registry; NCT04650529).
Study context
- Population
- Patients with coronary artery disease undergoing percutaneous coronary intervention (PCI) and receiving medical therapybiomarkers measured on admission and at 1 month following medical therapy post-PCI
- Participants
- 2,789 patients
- Exposure
- Quartiles of 1-month biomarker levels
- Outcome
- Major adverse cardiovascular events:
- Composite of cardiovascular death
- Myocardial infarction
- Stroke
- Follow-up
- Between 1 month and 4 years post-PCI
Main finding
As reported in the abstract
highest vs lowestHRP value
1-month hs-CRP, covariate-adjusted
1.71(95% CI 1.01–2.91)
1-month fibrinogen, covariate-adjusted
2.47(95% CI 1.40–4.36)
1-month fibrinogen, adjusted for covariates and biomarkers; strongest incremental predictor
2.23(CI 1.20–4.12)
P < 0.001- 1-month hs-CRP, intermediate quartiles
- 1.37 (0.78-2.41), 1.89 (1.11-3.21)
- 1-month fibrinogen, intermediate quartiles
- 1.49 (0.83-2.67), 1.83 (1.03-3.26)
- 1-month fibrinogen, adjusted for covariates and biomarkers, intermediate quartiles
- 1.45 [0.80-2.62], 1.65 [0.91-2.98]
Observational data: associations, not effects.
Further findings
Change in biomarker levels from admission to 1 month
- Biomarker levels decreased significantly
- all P values ≤ 0.001
- Except fibrinogen levels
- 329 ± 86 vs 359 ± 92 mg/dL; P < 0.001
Correlation between 1-month hs-CRP and fibrinogen
- highest correlation
- r = 0.426
Original publication
Residual Cardiovascular Biomarkers After Medical Therapy and Their Prognostic Implications Following Percutaneous Coronary Intervention. JACC Adv. Published 2 January 2026. doi:10.1016/j.jacadv.2025.102498
Summarised from the published abstract; every number is checked against it