Valvular & structural heart diseaseCohort study
Residual left atrial v wave predicts clinical outcome of transcatheter edge-to-edge mitral valve repair
- prospective observational study
Authors' conclusion
High residual LAvP predicts death or hospitalization for heart failure after M-TEER. LAvP after device implantation provides incremental prognostic information beyond echocardiographic MR grading and may therefore assist intraprocedural decision-making during M-TEER.
Study context
- Population
- Patients undergoing M-TEER for primary or secondary mitral regurgitation (MR)patients undergoing M-TEER
- Participants
- 299 patients
- Exposure
- Intraprocedural left atrial (LA) pressure as predictor of clinical outcome
- Outcome
- Death or hospitalization for heart failure
- Follow-up
- 2-year follow-up
Main finding
As reported in the abstract
LAvP post M-TEERHazard ratio per 10 mmHg (CI)P value
univariate analysis
1.37(1.15–1.63)
P < 0.001multivariate analysis, independent of echocardiographic MR severity
1.29(1.06–1.57)
P = 0.012Observational data: associations, not effects.
Further findings
Baseline characteristics
- Mean age
- 76.6 ± 8.2 years
- Secondary mitral regurgitation
- 62.9%
Reduction to MR grade I or II
- Reduction to MR grade I or II achieved
- 95.3%
LAvP before vs after device implantation
- LAvP decreased from
- 30.5 ± 15.0 to 23.2 ± 10.4 mmHg (P < .001)
LAmP before vs after device implantation
- modest reduction of LAmP from
- 16.6 ± 6.3 to 15.3 ± 5.9 mmHg (P = .006)
Original publication
Residual left atrial v wave predicts clinical outcome of transcatheter edge-to-edge mitral valve repair. ESC Heart Fail. Published 23 March 2026. doi:10.1093/eschf/xvag086
Summarised from the published abstract; every number is checked against it