Heart failure & cardiomyopathiesCohort study
Residual Pulmonary Hypertension and Clinical Outcomes in Acute Decompensated Heart Failure Patients Stratified By Left Ventricular Ejection Fraction
- Prospective cohort study
- multicentre
- registry (WET-HF)
Authors' conclusion
The prognostic importance of residual PH was comparable across both HF with reduced and preserved ejection fraction patients.
Study context
- Population
- Hospitalised patients with acute decompensated heart failure (HF) (WET-HF registry)
- Participants
- 1,702 patients
- Exposure
- Residual pulmonary hypertension (PH) vs no PH, stratified by left ventricular ejection fraction (LVEF)
- nonPH-HF with LVEF <50%n = 689reference
- PH-HF with LVEF <50%n = 291
- nonPH-HF with LVEF ≥50%n = 453
- PH-HF with LVEF ≥50%n = 269
- Outcome
- Composite of:
- All-cause mortality
- HF rehospitalisation
- Follow-up
- 2 years
Main finding
As reported in the abstract
Composite of:
- All-cause mortality and HF rehospitalisation
- PH vs no PH
P < 0.001
Observational data: associations, not effects.
Further findings
Outcomes by BNP improvement >30% vs less, nonPH-HF (subgroup)
Composite endpoint
All-cause mortality
HF rehospitalisation
- Outcomes by BNP improvement >30% vs less, nonPH-HF (subgroup): composite p < 0.001
- Outcomes by BNP improvement >30% vs less, nonPH-HF (subgroup): all-cause mortality p < 0.001
- Outcomes by BNP improvement >30% vs less, nonPH-HF (subgroup): HF rehospitalisation p = 0.001
Outcomes by BNP improvement, PH-HF (subgroup)
- No such difference evident
Original publication
Residual Pulmonary Hypertension and Clinical Outcomes in Acute Decompensated Heart Failure Patients Stratified By Left Ventricular Ejection Fraction. Eur J Heart Fail. Published 4 July 2025. doi:10.1002/ejhf.3755
Summarised from the published abstract; every number is checked against it