Valvular & structural heart diseaseCohort study
Residual Tricuspid Regurgitation After Tricuspid Transcatheter Edge-to-Edge Repair: Insights Into the EuroTR Registry
- Registry-based cohort study
- multicentre European registry
Authors' conclusion
T-TEER effectively reduced TR severity in the majority of patients. While residual TR ≥3+ was associated with worse outcomes, no differences were observed for residual TR 1+ versus 2+. Symptomatic improvement correlated with the degree of TR reduction.
Study context
- Population
- Patients undergoing tricuspid transcatheter edge-to-edge repair (T-TEER) in the EuroTR registry
- Participants
- 1,286 patients
- Exposure
- Residual tricuspid regurgitation (TR) ≥3+ vs lesser residual TR after T-TEER
- Outcome
- All-cause mortality and New York Heart Association (NYHA) functional class by residual TR
- Follow-up
- 2 years
Main finding
2-year all-cause mortality
Hazard ratio
2.06
95% CI 1.30–3.26
P = 0.002
By group
Residual TR ≥3+ vs Residual TR ≤1+
HR 2.06 (95% CI 1.30–3.26); P = 0.002
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Residual TR ≤1+ | Residual TR 2+ | Residual TR ≥3+ | P value |
|---|---|---|---|---|
| NYHA class ≥III at follow-up | 40.5% | Not reported in the abstract | 52.4% | P < 0.001 |
Residual TR at discharge
- TR ≤1+
- 42.4%
- TR 2+
- 40.0%
- TR 3+
- 14.9%
- TR ≥4+
- 2.8%
Symptomatic improvement vs degree of TR reduction
- Degree of TR reduction significantly correlated with symptomatic improvement
- P = 0.012
Predictors of residual TR ≥3+
- Prevalence four times higher with vena contracta >11.1 mm and tenting area >1.92 cm²
Original publication
Residual Tricuspid Regurgitation After Tricuspid Transcatheter Edge-to-Edge Repair: Insights Into the EuroTR Registry. Eur J Heart Fail. Published 29 May 2024. doi:10.1002/ejhf.3274
Summarised from the published abstract; every number is checked against it