Pulmonary vascular disease & thromboembolism
Restoration of right ventricular function in the treatment of pulmonary arterial hypertension
Main finding · Survival (death/lung transplantation)Result — go to the resultHazard ratio 1.91 95% CI 1.11–3.27Authors' conclusion
After treatment initiation, 60% of patients with PAH reach or maintain the 45% RVEF threshold, which is associated with a long-term stable RV function and favourable prognosis.
Study context
- Population
- Incident, treatment-naive adults with PAH with CMR at baseline and first follow-up
- Participants
- 127 participants
- Exposure
- Right ventricular ejection fraction (RVEF) ≥45% vs RVEF <45% at first follow-up
- RVEF≥45%@FUn = 75
- RVEF<45%@FUn = 52reference
- Outcome
- Survival (death/lung transplantation)
Main finding
As reported in the abstract
Hazard ratio
1.91
95% CI 1.11–3.27
RVEF<45%@FUvs RVEF≥45%@FU
HR 1.91 (95% CI 1.11–3.27)
Observational data: associations, not effects.
Further findings
| Outcome | PVR reduction 40% | PVR reduction <40% |
|---|---|---|
| ΔRVEF by PVR reduction ≥40% vs <40% | 17 ± 11 | 5 ± 8 |
- ΔRVEF by pulmonary vascular resistance (PVR) reduction ≥40% vs <40%: interaction P<0.001
Predictors of RVEF ≥45% at follow-up
- Baseline right ventricular (RV) end-diastolic volume and NT-proBNP were multivariable predictors
ΔRVEF by PVR reduction ≥40% vs <40%
- 40% PVR reduction did not guarantee an RVEF ≥45%
RVEF over subsequent visits in RVEF<45%@FU
- Patients failing the threshold at first follow-up mostly stayed below it over the next consecutive visits
Original publication
Restoration of right ventricular function in the treatment of pulmonary arterial hypertension. Heart. Published 1 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →