Heart failure & cardiomyopathies
Retrograde Conduction in Left Bundle Branch Block: Insights From Left Bundle Branch Pacing
Authors' conclusion
Bidirectional block in LBBB was characterized by advanced HF symptoms, while unidirectional block was associated with better clinical outcomes after cardiac resynchronization therapy by LBBP.
Study context
- Population
- Patients undergoing successful left bundle branch pacing (LBBP) for nonischemic cardiomyopathy with LV ejection fraction (LVEF) ≤35% and left bundle branch block (LBBB)mean follow-up 21.8 ± 13.1 months
- Participants
- 165 patients
- Exposure
- Unidirectional block vs bidirectional block during LBBP
- Group In = 136reference
- Group IIn = 29
- Outcome
- Retrograde conduction pattern
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Super-response (LVEF ≥50%)
P = 0.03
Composite of HF hospitalization, ventricular arrhythmias and mortality
P = 0.04
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Super-response (LVEF ≥50%)LVEF normalization | 4.1 (1.26–13.97) | P = 0.02 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Retrograde Conduction in Left Bundle Branch Block: Insights From Left Bundle Branch Pacing. JACC Clin Electrophysiol. Published 12 June 2024. doi:10.
Summarised from the published abstract; every number is checked against it