Revascularisation strategies for non-acute myocardial ischaemic syndromes
Authors' conclusion
This Bayesian network meta-analysis found that an initial CABG (+OMT) revascularisation strategy was associated with higher probabilities of optimal outcomes, with the exception of stroke, compared with an initial PCI (+OMT) revascularisation strategy, although CrIs overlapped, suggesting that some uncertainty remains.
Study context
- Population
- Patients with non-acute myocardial ischaemic syndromes in randomised controlled trials published between 2005 and 10 June 2025patients in 10 randomised controlled trials (RCTs)
- Participants
- 10,742 patients
- Comparison
- Comparative incremental effectiveness of coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) over medical therapy on long-term outcomes
- Outcome
- All-cause mortality
- Follow-up
- Maximum
Pooled result
As reported in the abstract
HR
CABG+OMTvs OMTestimated median HR
0.84(95% CI 0.68–1.07)
PCI+OMTvs OMTCrI
0.93(CrI 0.79–1.16)
CABG+OMTvs PCI+OMTCrI
0.91(CrI 0.71–1.13)
Further pooled results
SUCRA of CABG+optimal medical therapy (OMT) ranking as optimal revascularisation treatment
- Mortality
- 88.1%
- Myocardial infarction
- 99.7%
- Stroke
- 17.5%
- Re-revascularisation
- 99.5%
Sensitivity analyses
- Results were consistent across sensitivity analyses, including in the node-splitting models
Original publication
Revascularisation strategies for non-acute myocardial ischaemic syndromes. Heart. Published 14 September 2025. doi:10.
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