Heart failure & cardiomyopathiesCohort study
Revascularization and Outcomes in Ischaemic Left Ventricular Dysfunction After Heart Failure Admission: The RevascHeart Study
- Retrospective cohort study
- multicentre
Authors' conclusion
Revascularization did not outperform GDMT in ischaemic LV dysfunction following HF admission in this retrospective analysis.
Study context
- Population
- Patients admitted for heart failure (HF) with LV ejection fraction (LVEF) ≤40% and documented coronary artery disease (CAD), 2012–2023
- Participants
- 408 patients
- Exposure
- Revascularization vs guideline-directed medical therapy (GDMT)
- Outcome
- All-cause or CV mortality
- Follow-up
- median 44.6-month follow-up
Main finding
As reported in the abstract
median 44.6 months
Revascularization vs GDMTHazard ratio (95% CI)P value
all-cause mortality, multivariate
0.81(0.48–1.39)
P = 0.45CV mortality, multivariate
0.97(0.62–1.52)
P = 0.90Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality by type of revascularization — CABG vs GDMT | 0.74 (0.51–1.08) | P = 0.13 | |
| Mortality by type of revascularization — PCI vs GDMT | 0.98 (0.62–1.55) | P = 0.93 | |
| 0.512Hazard ratio (log scale) |
Left ventricular (LV) reverse remodelling
- Both groups had significant reductions in LV size and improvements in LVEF, greater with revascularization
Original publication
Revascularization and Outcomes in Ischaemic Left Ventricular Dysfunction After Heart Failure Admission: The RevascHeart Study. Eur J Heart Fail. Published 2 October 2024. doi:10.1002/ejhf.3463
Summarised from the published abstract; every number is checked against it