Heart failure & cardiomyopathies
Right Ventricular Global Work Efficiency: A Reliable Non-Invasive Estimate of Right Ventricular Contractility
Authors' conclusion
RVGWE is comparable between HF patients with and without PH and remains stable across different haemodynamic conditions.
Study context
- Population
- HFrEF patients undergoing right heart catheterization and echocardiography
- Participants
- 102 patients
- Exposure
- Heart failure (HF) patients with PH vs without PH; before vs after vasodilator reversibility test
- PHn = 53
- No PHn = 49reference
- Outcome
- Variations of RV myocardial work components (RV global work index, constructive work, wasted work [RVGWW], work efficiency [RVGWE])
Methodological detailssingle-centre, consecutive enrolment
- Single-centre
- Consecutive enrolment
Main finding
As reported in the abstract
RVGWE
P = 0.332
Observational data: associations, not effects.
Further findings
PH subtype (PH patients)
- Combined PH
- 27/52 (51.9%)
- Isolated post-capillary PH
- 25/52 (48.1%)
Reversibility test in combined PH
- Reversibility test performed
- 26/27 (96.2%)
- Pulmonary pressure normalization
- 16/26 (61.5%)
RV global work efficiency (RVGWE) change with PH normalization (from → to)
- RVGWE remained almost unchanged, from 82.8 ± 6.9% to 85.3 ± 6.6%
- P = 0.596
RV global wasted work (RVGWW) change with PH normalization (from → to)
- RVGWW significantly decreased, from 60 (49-90) mmHg% to 41 (31-53) mmHg%
- P = 0.027
Variability of right ventricular (RV) function parameters during reversibility test
- RVGWE least variable of all echocardiographic and haemodynamic parameters; mean variation
- 3 ± 10%
Original publication
Right Ventricular Global Work Efficiency: A Reliable Non-Invasive Estimate of Right Ventricular Contractility. ESC Heart Fail. Published 3 July 2025. doi:10.
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