Coronary disease & ACSSecondary analysis
Right Ventricular to Pulmonary Arterial Uncoupling Is Associated With 1-Year Mortality in ST-Segment Elevation Myocardial Infarction
- Post hoc analysis of a retrospective cohort study
- derivation and validation cohorts
- external validation cohort
Authors' conclusion
RV-PA uncoupling (TAPSE/sPAP ratio < 0.405 mm/mm Hg) is an independent predictor of 1-year all-cause mortality in these patients, aiding in early risk stratification.
Study context
- Population
- STEMI patients undergoing primary PCI, 2014–2023median follow-up 4.2 years
- Participants
- 973 patients
- Comparison
- RV-PA uncoupling vs preserved RV-PA coupling
- Primary endpoint
- All-cause mortality
- Follow-up
- 1 year
Primary result
1-year all-cause mortality
Hazard ratio
12.60
95% CI 4.49–35.40
P < 0.001
By group
RV-PA uncoupling vs Preserved RV-PA coupling
HR 12.60 (95% CI 4.49–35.40); P < 0.001
As reported in the abstract
Further findings
| Outcome | TAPSE/sPAP | TAPSE | P value |
|---|---|---|---|
| Prediction of 1-year mortality: TAPSE/sPAP vs TAPSE alone (ROC) | P = 0.018 | ||
| AUC | 0.732 [95% CI: 0.643-0.821] | 0.643 [95% CI: 0.537-0.732] |
Original publication
Right Ventricular to Pulmonary Arterial Uncoupling Is Associated With 1-Year Mortality in ST-Segment Elevation Myocardial Infarction. JACC Cardiovasc Interv. Published 29 January 2026. doi:10.1016/j.jcin.2025.12.003
Summarised from the published abstract; every number is checked against it