Prevention & lipidsMeta-analysis
Risk and incidence of cardiovascular disease associated with polycystic ovary syndrome
- Systematic review and meta-analysis with population attributable fraction modelling
- Global Burden of Diseases 2019 data
Authors' conclusion
Women with PCOS have a significantly increased risk of CVD.
Study context
- Population
- Women; global burden 1990–2019five databases
- Comparison
- Polycystic ovary syndrome (PCOS) vs no PCOS
- Outcome
- Risk of CVD in women with PCOS
Pooled result
As reported in the abstract
CVD risk
PCOS vs No PCOSPooled relative risk (95% CI)
all ages
1.51(1.36–1.69)
10- to 54-year-olds
1.37(1.17–1.59)
Further pooled results
Global PCOS-associated cardiovascular disease (CVD) cases, all ages · 1990 to 2019
- Cases rose from 102 530 to 235 560
Most affected region in 2019
- East Asia and the Pacific
- 108 430 (66 090-166 150)
Temporal trend of PCOS-associated CVD age-standardized rate (ASIR) (estimated annual percentage change (EAPC))
- South Asia, highest increase
- 2.61% (2.49-2.73)
- 10–54 age group
- 0.49% (0.41-0.56)
- All-age group
- 0.34 (0.27-0.42)
- Middle- or low-middle sociodemographic index countries had higher increase trend over 30 years
Original publication
Risk and incidence of cardiovascular disease associated with polycystic ovary syndrome. Eur J Prev Cardiol. Published 19 February 2024. doi:10.1093/eurjpc/zwae066
Summarised from the published abstract; every number is checked against it