Arrhythmias & electrophysiologyDiagnostic or prognostic study
Risk assessment in patients with symptomatic and asymptomatic pre-excitation
- Prospective diagnostic accuracy study
- consecutive patients
Authors' conclusion
Sudden loss of pre-excitation during EST has a low NPV in excluding high-risk APs.
Study context
- Population
- Consecutive asymptomatic and symptomatic patients with pre-excitation referred for risk assessment59 asymptomatic, 105 symptomatic
- Participants
- 164 participants
- Comparison
- Low-risk exercise stress test (EST) findings vs electrophysiology study (EPS)
- Low-risk ESTn = 45
- Asymptomaticn = 59
- Symptomaticn = 105
- Outcome
- Accuracy of low-risk EST for excluding SPERRI/APERP ≤ 250 ms at EPS
Performance
As reported in the abstract
Low-risk EST for excluding SPERRI/APERP ≤ 250 ms
| Test or model | Value | Sensitivity | Specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|---|
| Low-risk EST | 27% | 40% | 91% | 87% | 51% | 60% |
- Low-risk EST findings with SPERRI/accessory pathway effective refractory period (APERP) ≤ 250 ms at EPS (2 asymptomatic)
- 6
Further findings
| Outcome | Low-risk EST | Asymptomatic | Symptomatic |
|---|---|---|---|
| Inducible arrhythmia at EPS | Not reported in the abstract | 69% | 61% |
Inducible arrhythmia at EPS
- Similar in asymptomatic and symptomatic
Original publication
Risk assessment in patients with symptomatic and asymptomatic pre-excitation. Europace. Published 15 February 2024. doi:10.1093/europace/euae036
Summarised from the published abstract; every number is checked against it