Risk factor variability and cardiovascular risk among patients with diabetes: a nationwide observational study
Authors' conclusion
Combined high variability of two risk factors, particularly body weight and blood pressure, is associated with cardiovascular risk among patients with T2DM.
Study context
- Population
- People with T2DM without cardiovascular disease (CVD) at baseline and with at least five risk-factor measurements
- Participants
- 29,471 people
- Exposure
- Recursive partitioning and amalgamation (RECPAM) risk classes defined by risk-factor variability vs low variability of both body weight and total cholesterol
- Outcome
- MI, stroke and all-cause mortality
- Follow-up
- 4.80 (2.40-6.70) years following the exposure phase
Methodological detailsnationwide, registry-derived
- Nationwide
- Registry-derived
Main finding
As reported in the abstract
Each group vs class 1Hazard ratio (95% CI)
Class 6
1.81(1.61–2.05)
Class 5
1.57(1.28–1.68)
Class 4
1.33(1.20–1.49)
Class 3
1.12(1.00–1.25)
Class 2
1.14(1.00–1.30)
Observational data: associations, not effects.
Original publication
Risk factor variability and cardiovascular risk among patients with diabetes: a nationwide observational study. Eur J Prev Cardiol. Published 10 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →