Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis
Authors' conclusion
The detection rate of CoA may improve when a multiple-criteria prediction model is adopted.
Study context
- Population
- Fetuses at risk for coarctation of the aorta on prenatal ultrasound
- Participants
- 922 fetuses · 12 studies
- Comparison
- Fetuses with coarctation of the aorta (CoA) vs without CoA
- Outcome
- Strength of association and diagnostic accuracy of ultrasound signs in predicting CoA prenatally
Methodological detailsrandom-effects, hierarchical summary ROC model
- Random-effects
- Hierarchical summary ROC model
Pooled result
As reported in the abstract
Ultrasound signs, CoA vs no CoA
CoA vs No CoAOdds ratio (95% CI)P value
Coarctation shelf
26.0(4.42–153)
P < 0.001Aortic arch hypoplasia
38.2(3.01–486)
P = 0.005- Mitral valve diameter z score lower with CoA
- P < 0.001
- Tricuspid valve diameter z score higher with CoA
- P = 0.01
- Aortic valve diameter z score lower with CoA
- P ≤ 0.001
- Ascending aorta diameter similar (z score; mm)
- P = 0.07 and 0.47
- Aortic isthmus diameter z score lower with CoA, sagittal view
- P = 0.02
- Aortic isthmus diameter z score lower with CoA, 3-vessel trachea view
- P < 0.001
- Pulmonary artery diameter z score higher with CoA
- P < 0.001
- RV/LV diameter ratio higher with CoA
- P = 0.02
- Pulmonary artery/ascending aorta diameter ratio higher with CoA
- P = 0.02
- Aortic isthmus/arterial duct diameter ratio lower with CoA
- P < 0.001
- Persistent left superior vena cava: no increased risk
- P = 0.85
- Ventricular septal defect: no increased risk
- P = 0.12
- Bicuspid aortic valve: no increased risk
- P = 0.14
Original publication
Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis. Circulation. Published 29 December 2016. doi:10.
Summarised from the published abstract; every number is checked against it