Heart failure & cardiomyopathies
Risk Factors for Intracardiac Thrombus in Peripartum Cardiomyopathy: A Retrospective Study in China
Authors' conclusion
In our retrospective study, impaired LVEF, elevated haemoglobin levels, and high thrombocyte counts were regarded as independent risk factors for intracardiac thrombus in PPCM.
Study context
- Population
- Patients with peripartum cardiomyopathy (PPCM) in China159 suspected cases screened
- Participants
- 123 patients
- Exposure
- Derivation vs Validation
- Derivationn = 83
- Validationn = 40
- Outcome
- Intracardiac thrombus
Methodological detailsrisk prediction model development with internal validation
- Risk prediction model development with internal validation
Main finding
As reported in the abstract
Independent risk factors for intracardiac thrombus (multivariable logistic regression)
Odds ratio (95% CI)P value
LVEF
0.772(0.665–0.897)
P = 0.001Haemoglobin levels
1.050(1.003–1.099)
P = 0.038Thrombocyte counts
1.018(1.006–1.029)
P = 0.003- Patients with intracardiac thrombus
- 22
Observational data: associations, not effects.
Further findings
Discrimination of risk stratification model (C-index)
- C-index, derivation cohort
- 0.916 (95% CI: 0.850-0.982, P < 0.001)
- C-index, internal validation
- 0.790 (95% CI: 0.644-0.936, P = 0.017)
- Score ≤7 low risk, 8-10 intermediate risk, ≥11 high risk
Original publication
Risk Factors for Intracardiac Thrombus in Peripartum Cardiomyopathy: A Retrospective Study in China. ESC Heart Fail. Published 21 September 2022. doi:10.
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