Coronary disease & ACSResearch article
Risk in Women Emerges at Lower Coronary Plaque Burden Than in Men: PROMISE Trial
- Analysis of the PROMISE coronary computed tomography angiography arm
- sex-stratified spline Cox models
Authors' conclusion
In women, major adverse cardiovascular events appeared to emerge at a lower PB, and to rise more sharply. Findings support sex-specific interpretation of coronary computed tomography angiography-derived plaque metrics for timely intervention in women.
Study context
- Population
- Women and men with stable chest pain in the PROMISE coronary computed tomography angiography arm2,199 women
- Participants
- 4,267 participants
- Comparison
- Cardiovascular risk trajectories across quantitative coronary plaque measures in women and men
- womenn = 2,199
Main finding
As reported in the abstract
- plaque was less frequent in women
- P < 0.001
Further findings
Incident major adverse cardiovascular events (death, myocardial infarction, or unstable angina hospitalization) · median 26 months (interquartile range, 18-34) · described as similar
Major adverse cardiovascular event risk by total PB
hazard ratio crossed 1.0 at
hazard ratio 1.5 at
Major adverse cardiovascular event risk by noncalcified PB
crossing hazard ratio 1.0 at
hazard ratio 1.5 at
Adjustment for atherosclerotic cardiovascular disease risk score
- Findings were similar after adjustment for atherosclerotic cardiovascular disease risk score
Original publication
Summarised from the published abstract; every number is checked against it