Acute cardiac care & resuscitationCohort study
Risk of cardiovascular events according to the severity of an exacerbation of chronic obstructive pulmonary disease
- Case-crossover study
- nationwide hospital discharge database
Authors' conclusion
Following hospitalization for exCOPD, the risk of cardiovascular complications is increased.
Study context
- Population
- Patients with COPD hospitalized for a CV event in France in 2018–19, with ≥1 hospitalization for exacerbated chronic obstructive pulmonary disease (exCOPD) ≤24 weeks before
- Participants
- 9,840 patients
- Exposure
- Hospitalization for exCOPD ≤1-4 weeks vs 9-24 weeks before the CV event
- Outcome
- Hospitalization for a CV event (CVE), by type
Main finding
As reported in the abstract
Any CVE · ≤4 weeks after exCOPD hospitalization
≤1-4 weeks vs 9-24 weeksOdds ratio (95% CI)
any exCOPD
3.03(2.90–3.16)
exCOPD requiring mechanical ventilation
6.99(6.09–8.03)
Observational data: associations, not effects.
Further findings
CVE risk ≤4 weeks after exCOPD hospitalization requiring mechanical ventilation
- CVE risk seven times greater if mechanical ventilation was necessary, OR
- 6.99 (95% CI 6.09-8.03)
Risk by type of CVE after exCOPD hospitalization
- NSTEMI, OR (95% CI 4.47-6.34); highest among CVE
- 5.33
- STEMI, OR
- 4.24
- Resuscitated cardiac arrest, OR
- 4.33
- PE, OR
- 4.02
- AF/flutter, OR
- 3.03
- Ischaemic stroke, OR
- 1.93
- Limb events, OR
- 1.34
- significantly increased (P <0.05) for many other cardiovascular events (CVEs)
Fatal CVEs
- CVEs that were fatal
- Ten percent
Original publication
Risk of cardiovascular events according to the severity of an exacerbation of chronic obstructive pulmonary disease. Eur J Prev Cardiol. Published 20 February 2025. doi:10.1093/eurjpc/zwaf086
Summarised from the published abstract; every number is checked against it