Heart failure & cardiomyopathiesCohort study
Risk of heart failure in inflammatory bowel disease: a Swedish population-based study
- Population-based matched cohort study
- nationwide
- matched with up to five general population reference individuals
- sibling-controlled analysis
Authors' conclusion
Patients with IBD had a moderately higher risk of developing HF for ≥20 years after IBD diagnosis than the general population.
Study context
- Population
- Patients with biopsy-confirmed inflammatory bowel disease (IBD) in Sweden, followed until 31 December 2019matched cohort
- Participants
- 81,749 / 382,190 / 95,239
- Exposure
- IBD vs matched general population reference individuals
- IBDn = 81,749
- Reference individualsn = 382,190reference
- Siblingsn = 95,239reference
- Outcome
- Incident HF
- Follow-up
- Median 12.4 years
Main finding
HF
Adjusted hazard ratio
1.19
95% CI 1.15–1.23
Events by group
IBD
50.3/10 000 person-years
5582 of 81 749
Reference individuals
37.9
20 343 of 382 190
IBD vs Reference individuals
aHR 1.19 (95% CI 1.15–1.23)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | |
|---|---|---|
| HF by IBD subtype (subgroup) — CD vs Reference individuals · IR: 46.9 vs. 34.4 | 1.28 (1.20–1.36) | |
| HF by IBD subtype (subgroup) — UC vs Reference individuals · IR: 50.1 vs. 39.7 | 1.14 (1.09–1.19) | |
| HF by IBD subtype (subgroup) — IBD-U vs Reference individuals · IR: 60.9 vs. 39.0 | 1.28 (1.16–1.42) | |
| HF, sibling-controlled analysis · slightly attenuated association | 1.10 (1.03–1.19) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Risk of heart failure in inflammatory bowel disease: a Swedish population-based study. Eur Heart J. Published 21 May 2024. doi:10.1093/eurheartj/ehae338
Summarised from the published abstract; every number is checked against it