Arrhythmias & electrophysiologySecondary analysis
Risk of stroke and other adverse outcomes in patients with perioperative atrial fibrillation 1 year after non-cardiac surgery
- Secondary analysis of the POISE-1 and POISE-2 randomised trials
- pooled datasets
- multivariable adjusted Cox proportional hazards models
Authors' conclusion
Patients with POAF have a significantly increased risk of stroke, MI, and death at 1 year.
Study context
- Population
- Patients with, or at risk of, CVD undergoing non-cardiac surgery (POISE-1 and POISE-2), excluding those in atrial fibrillation (AF) at randomization404 had perioperative atrial fibrillation (POAF) (2.2%)
- Participants
- 18,117 participants
- Comparison
- POAF vs no POAF after non-cardiac surgery
- POAFn = 404
- Primary endpoint
- Incidence of stroke
- Follow-up
- 1 year
Primary result
Stroke · 1 year after surgery
Adjusted hazard ratio
3.43
95% CI 2.00–5.90
P < 0.001
By group
POAF vs No POAF
aHR 3.43 (95% CI 2.00–5.90); P < 0.001
As reported in the abstract
Secondary outcomes
| Outcome | POAF | No POAF | aHR (95% CI) | P value | |
|---|---|---|---|---|---|
| Death | 31.37 | 9.34 | 2.51 (2.01–3.14) | P < 0.001 | |
| MI | 26.20 | 8.23 | 5.10 (3.91–6.64) | P < 0.001 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Original publication
Risk of stroke and other adverse outcomes in patients with perioperative atrial fibrillation 1 year after non-cardiac surgery. Eur Heart J. Published 25 June 2019. doi:10.1093/eurheartj/ehz431
Summarised from the published abstract; every number is checked against it