Cardio-oncology & otherMeta-analysis
Risk Stratification in Cardiac Sarcoidosis With Cardiac Positron Emission Tomography
- Systematic review and meta-analysis of prognostic studies
Authors' conclusion
Multiple cardiac PET parameters provide risk stratification value in cardiac sarcoidosis. Focal right ventricular uptake and a lack of response to immunosuppressive therapy on serial PET imaging were particularly predictive of MACE.
Study context
- Population
- Patients with cardiac sarcoidosis undergoing positron emission tomography (PET) imaging
- Participants
- 5,250 patients · 55 studies
- Comparison
- Abnormal vs normal cardiac PET findings
- Outcome
- Major adverse cardiac events (MACE)
Pooled result
As reported in the abstract
Odds ratio (95% CI)P value
Abnormal FDG uptake and perfusion defect (combined)
2.86(1.74–4.71)
P < 0.0001Abnormal perfusion or FDG uptake
2.69(1.67–4.33)
Abnormal FDG uptake
2.61(1.51–4.50)
Focal abnormal right ventricular uptake
6.27(3.19–12.32)
P < 0.00001Lack of response to immunosuppression on serial PET
8.43(3.25–21.85)
P < 0.0001Further pooled results
Risk of bias (QUIPS)
- Low to moderate risk of bias, particularly given small sample sizes of individual studies
Original publication
Risk Stratification in Cardiac Sarcoidosis With Cardiac Positron Emission Tomography. JACC Cardiovasc Imaging. Published 7 August 2024. doi:10.1016/j.jcmg.2024.05.013
Summarised from the published abstract; every number is checked against it