Heart failure & cardiomyopathiesCohort study
Risk stratification with the Haemodynamic Gain Index and peak rate-pressure product in patients with chronic heart failure undergoing treadmill exercise testing
- Retrospective cohort study
- consecutive patients
Authors' conclusion
Both HGI and peak RPP are predictors of mortality in patients with chronic HF and may be tools to signal the need for advanced HF therapy evaluation.
Study context
- Population
- Patients with symptomatic heart failure (HF) undergoing treadmill exercise testing for symptom evaluation, January 1991 to February 20152,222 (37.4%) died
- Participants
- 5,940 patients
- Exposure
- Haemodynamic Gain Index (HGI) and peak rate-pressure product (RPP) and all-cause mortality
- Outcome
- All-cause mortality
- Follow-up
- Median 7.1 years
Main finding
As reported in the abstract
All-cause mortality (adjusted HR per SD increase)
Adjusted hazard ratio (CI)P value
HGI
0.80(0.73–0.88)
P < 0.001peak RPP
0.85(0.78–0.91)
P < 0.001Per SD increase, as printed
- Deaths
- 2222 (37.4%)
Observational data: associations, not effects.
Further findings
Optimal cut-off values for discriminating all-cause mortality
- HGI cut-off
- 1.06
- Peak RPP cut-off
- 180 966
Original publication
Risk stratification with the Haemodynamic Gain Index and peak rate-pressure product in patients with chronic heart failure undergoing treadmill exercise testing. Eur J Prev Cardiol. Published 6 February 2025. doi:10.1093/eurjpc/zwaf046
Summarised from the published abstract; every number is checked against it