Cohort study
Role of Arrhythmic Phenotype in Prognostic Stratification and Management of Dilated Cardiomyopathy
- Multicentre cohort study
Authors' conclusion
In DCM patients, the combination of early detected NSVT and unexplained syncope increases the risk of life-threatening arrhythmic outcomes and can aid the identification of carriers of malignant arrhythmogenic genotypes.
Study context
- Population
- Dilated cardiomyopathy (DCM) patients with available genetic testing
- Participants
- 742 patients
- Exposure
- DCM with vs without arrhythmic markers
- Outcome
- Composite of:
- SCD
- Major ventricular arrhythmias (SCD/MVA)
- Follow-up
- Median 6 years (IQR 1.6-12.1)
Main finding
As reported in the abstract
SCD/MVA · median 6 years
- Unexplained syncope and non-sustained ventricular tachycardia (NSVT) were the only arrhythmic markers associated with SCD/MVA
- Combination of syncope and NSVT carried a significant additive risk of SCD/MVA, incremental to LVEF and NYHA class
Observational data: associations, not effects.
Further findings
Probability of arrhythmogenic genotype (LMNA, FLNC, RBM20, desmosomal)
- Rose with both early syncope and NSVT present
- 8% to 30%
Original publication
Role of Arrhythmic Phenotype in Prognostic Stratification and Management of Dilated Cardiomyopathy. Eur J Heart Fail. Published 26 February 2024. doi:10.1002/ejhf.3168
Summarised from the published abstract; every number is checked against it