Acute cardiac care & resuscitation
Role of EEG spindle-like activity in post cardiac arrest prognostication
Authors' conclusion
Spindle-like EEG activity may orient on prognostication of favorable outcome in adult post CA patients, and correlates with lower neuronal damage.
Study context
- Population
- Comatose adults after cardiac arrest, institutional registry 09.2021–09.2023
- Participants
- 276 adults
- Exposure
- Spindle-like EEG activity vs none
- Spindle-like activityn = 66
- Outcome
- Favorable outcome (CPC 1-2)
- Follow-up
- 3 months
Methodological detailsprospective institutional registry
- Prospective institutional registry
Main finding
As reported in the abstract
Prognostic performance of EEG features for CPC 1-2
| Group | Sensitivity | Specificity |
|---|---|---|
| Spindle-like activity | 36.8 % | 82.2 % |
| Modified benign EEG | 90.5 % | — not stated in the abstract |
| Modified benign EEG + spindle-like activity | 95.8 % | 54.4 % |
Sensitivity
Spindle-like activity36.8 %
Modified benign EEG90.5 %
Modified benign EEG + spindle-like activity95.8 %
Specificity
Spindle-like activity82.2 %
Modified benign EEG— not stated in the abstract
Modified benign EEG + spindle-like activity54.4 %
— not stated in the abstract
- Modified benign EEG + spindle-like activity vs Modified benign EEG: P < 0.001 — from 90.5 % to 95.8 %
Observational data: associations, not effects.
Further findings
Peak serum NSE at 24-48 h · significantly lower NSE with spindles
P < 0.001
- Peak serum neuron-specific enolase (NSE) at 24-48 h: IQR printed as 16.1-24.4 (as in abstract)
Original publication
Role of EEG spindle-like activity in post cardiac arrest prognostication. Resuscitation. Published 18 October 2024. doi:10.
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