Heart failure & cardiomyopathies
Role of Ejection Fraction in Patients at Risk for Advanced Heart Failure: Insights from the HELP-HF Registry
Main finding · All-cause deathResult — go to the resultAdjusted hazard ratio 0.67 95% CI 0.48–0.94Authors' conclusion
Among patients with HF and at least one 'I NEED HELP' marker for advanced HF, left ventricular EF is still of prognostic value.
Study context
- Population
- Patients with heart failure (HF) and at least one high-risk 'I NEED HELP' marker for advanced HF (mean age 75.1 years, 67.6% hospitalized)
- Participants
- 1,149 patients
- Exposure
- HFpEF and HFmrEF vs HFrEF
- HFrEFn = 699reference
- HFmrEFn = 122
- HFpEFn = 328
- Outcome
- All-cause death
- Follow-up
- Median 260 days
Methodological detailsmulticentre (four centres)
- Multicentre (four centres)
Main finding
As reported in the abstract
Adjusted hazard ratio
0.67
95% CI 0.48–0.94
P = 0.022
By group
HFrEF
28.3%
HFmrEF
26.2%
HFpEF
20.1
HFpEF vs HFrEF
adjusted HR 0.67 (95% CI 0.48–0.94); P = 0.022
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| All-cause death per 5% increase in EF (continuous)Multivariable adjustment | 0.94 (0.89–0.99) | P = 0.017 | |
| CV death per 5% increase in EF (continuous)Multivariable adjustment | 0.94 (0.88–1.00) | P = 0.049 | |
| 0.512Adjusted hazard ratio (log scale) |
Mortality with HF medical therapy, by ejection fraction (EF) < 50% and EF ≥ 50%
- Beta-blockers and renin-angiotensin system inhibitors or sacubitril/valsartan associated with lower mortality in both EF groups
Original publication
Role of Ejection Fraction in Patients at Risk for Advanced Heart Failure: Insights from the HELP-HF Registry. ESC Heart Fail. Published 16 October 2023. doi:10.
Summarised from the published abstract; every number is checked against it