HypertensionCohort study
Role of natriuretic peptides and cardiac troponins in staging hypertensive heart disease: the REMODEL study
- Prospective cohort study
Authors' conclusion
NT-proBNP and hsTnT are complementary biomarkers that not only predict cardiovascular outcomes and but also reflect the severity of cardiac remodelling in HHD.
Study context
- Population
- Asymptomatic individuals with essential hypertension and no prior CVD
- Participants
- 1,054 individuals
- Exposure
- Biomarker strata by NT-proBNP and hsTnT elevation
- Outcome
- Composite of:
- ACS
- HF hospitalization
- Stroke
- All-cause mortality
- Follow-up
- Median 53 (23, 72) months
Main finding
As reported in the abstract
CV events
Hazard ratio (95% CI)
High-risk
17.11(8.12–36.09)
Intermediate-risk
3.44(1.71–6.94)
- Event rates differed significantly across biomarker strata
- log-rank P < .001
Observational data: associations, not effects.
Further findings
Cardiovascular magnetic resonance (CMR) phenotype
- High-risk showed the most adverse CMR phenotype: increased myocardial mass, greater diffuse and replacement fibrosis, impaired LV strain, higher left atrial volumes
Original publication
Role of natriuretic peptides and cardiac troponins in staging hypertensive heart disease: the REMODEL study. Eur J Heart Fail. Published 8 January 2026. doi:10.1093/ejhf/xuaf001
Summarised from the published abstract; every number is checked against it