Arrhythmias & electrophysiology
Role of reverse remodelling in recurrence of atrial fibrillation after patient-tailored catheter ablation
Authors' conclusion
This study highlights the importance of RR for therapy success, with a novel targeted CA technique ensuring <5% AF recurrence in patient-specific simulations. After clinical validation, this approach can help improve long-term patient outcomes.
Study context
- Population
- Atrial fibrillation (AF) patients whose LGE-MRI scans were used to reconstruct left atrial (LA) models coupled with the Courtemanche-Ramirez-Nattel (CRN) electrophysiology modelAF patients whose LGE-MRI scans were used to reconstruct LA models
- Participants
- 15 patients
- Comparison
- Targeted ablation of RDs, with pulmonary vein isolation (PVI) applied as a reference; AF recurrence tested under three levels of ERR (0%, 50%, and 100%), with and without structural reverse remodelling (SRR)
- Outcome
- Acute AF termination with targeted ablation
Methodological detailsin-silico
- In-silico
Main finding
As reported in the abstract
- Targeted ablation acutely terminated AF in all patient-specific models
Further findings
AF recurrence · After the first procedure
Without SRR
With SRR
AF recurrence rate · After the second CA procedure
Without SRR
With SRR
Original publication
Role of reverse remodelling in recurrence of atrial fibrillation after patient-tailored catheter ablation. Europace. Published 2 November 2026. doi:10.
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