Valvular & structural heart disease
Routine revascularization with percutaneous coronary intervention in patients with coronary artery disease undergoing transcatheter aortic valve implantation – the third nordic aortic valve intervention trial – NOTION-3
Study context
- Population
- Patients with severe AS and significant coronary artery disease (CAD) (≥1 significant percutaneous coronary intervention (PCI)-eligible stenosis: Fractional flow reserve (FFR) ≤0.80 and/or diameter stenosis >90%) planned for transcatheter aortic valve implantation (TAVI)452 planned
- Planned comparison
- FFR-guided PCI vs medical treatment of CAD, in addition to TAVI
- Primary endpoint
- Composite of:
- First occurring all-cause mortality
- MI
- Urgent revascularization (PCI or CABG during unplanned hospital admission)
- Follow-up
- Until the last included patient has been followed for 1 year after TAVI
Methodological detailsdesign paper, open-label, investigator-initiated, multicentre, multinational
- Design paper
- Open-label
- Investigator-initiated
- Multicentre
- Multinational
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Routine revascularization with percutaneous coronary intervention in patients with coronary artery disease undergoing transcatheter aortic valve implantation – the third nordic aortic valve intervention trial – NOTION-3. Am Heart J. Published 8 October 2022. doi:10.
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