Arrhythmias & electrophysiologyCohort study
Safety and Efficacy of Temperature-Guided Radiofrequency Ablation for Ventricular Tachycardia
- multicenter cohort study
- consecutive patients
- 8 referral centers in Europe and the United States
- propensity score-matched
Authors' conclusion
In this multicenter VT ablation registry, a novel temperature-guided ablation modality showed favorable safety and efficacy relative to power-controlled ablation.
Study context
- Population
- Patients undergoing ventricular tachycardia (VT) ablation, 2021–2024Propensity score matching yielded 101 pairs · temperature-guided ablation 109 · power-controlled ablation 177
- Participants
- 286 patients
- Exposure
- temperature-guided VT ablation vs standard power-controlled ablation
- temperature-guidedn = 109
- power-controlledn = 177reference
- Outcome
- Sustained VT/ventricular fibrillation recurrence (primary efficacy endpoint)
- Follow-up
- Median 24 months
Main finding
As reported in the abstract
Recurrence rates similar between groups, overall cohort (log-rank test)
P = 0.570
Recurrence rates similar between groups, matched cohort (log-rank test)
P = 0.850
Observational data: associations, not effects.
Further findings
Baseline: ischemic cardiomyopathy as VT substrate
- Ischemic cardiomyopathy
- n = 125 [44%]
- Approximately one-half presented with electrical storm
Subgroup analyses
- No signal of heterogeneity
Safety
Procedure-related complications (primary safety endpoint)
| Outcome | adjusted OR | P value |
|---|---|---|
| Nonvascular complications (multivariable analysis) · lower odds with temperature-guided ablation | 0.095 | P = 0.028 |
- Procedure-related complications (primary safety endpoint): overall cohort P = 0.003
- Procedure-related complications (primary safety endpoint): matched: temperature-guided n = 3 [3%] vs power-controlled n = 12 [12%]; P = 0.028
- Procedure-related complications (primary safety endpoint): excluding vascular complications: temperature-guided n = 1 [1%] vs power-controlled n = 14 [8%]; P = 0.012
Original publication
Safety and Efficacy of Temperature-Guided Radiofrequency Ablation for Ventricular Tachycardia. JACC Clin Electrophysiol. Published 26 February 2026. doi:10.1016/j.jacep.2026.01.012
Summarised from the published abstract; every number is checked against it